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Primeva Labs
Mitochondrial-Derived Peptide

MOTS-c

MOTS-cMitochondrial ORF of the 12S rRNA-c

MOTS-c from Primeva Labs is offered strictly for research use only. Each order includes batch-specific CoA documentation, quality verification, and secure online ordering. Not for human or animal consumption.

Research Catalog Access
Complimentary research account required
Available formats10mg · 40mg

Primeva Labs supplies materials strictly for laboratory and research use. Create a complimentary research account to view current pricing, availability, and ordering.

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CoA

What Is MOTS-c?

Research overview

MOTS-c is a mitochondrial-derived peptide encoded in the 12S rRNA region, studied as a regulator of metabolic homeostasis and an exercise-mimetic in research models.

  • 16-amino-acid mitochondrial-derived peptide (encoded in 12S rRNA)
  • Studied for AMPK activation and insulin sensitivity
  • Described in literature as an exercise-mimetic in metabolic models
  • Supplied strictly as a research-grade reference material

Research Applications

Studied in preclinical research models · not for human use

Insulin-sensitivity research

Studied for improved glucose handling in aged and diet-induced obese models.

Exercise-mimetic studies

Investigated for adaptations resembling physical activity in mice.

Metabolic-homeostasis research

Examined for effects on weight, fat accumulation, and metabolic flexibility.

Mitochondrial-aging models

Explored for declining levels with age and links to metabolic decline.

Proposed Mechanisms

Preclinical · proposed pathways

AMPK activation

Activates the AMPK energy-sensing pathway in skeletal muscle in preclinical models.

Glucose handling

Associated with increased GLUT4 expression and insulin-stimulated glucose uptake.

Nuclear translocation

Translocates to the nucleus under metabolic stress to regulate gene expression.

Beta-oxidation

Studied for promotion of fat oxidation and reduced fat accumulation.

Mechanisms described above are drawn from preclinical (cell and animal) research and, where noted, early clinical literature. They are provided for educational context and should not be read as clinical or therapeutic claims.

Sources & References

Peer-reviewed research

Quality Verification cGLP · USP

Third-party tested by Analytical Formulations, Inc. · 2 certificates
LATEST6-PANELSELECTED DOSAGE
99.5%
PURITY
Passed full 6-panel
View COA
VariantMOTS-c 40mg
Lot #
Labeled40mg
Actual45.60mg
TestedApr 14, 2026
FULL 6-PANEL6× tested
Qualitative IDLambda MaxConfirmed
Percent PurityCorr. Coeff.99.5%
Quantitative AssayBeer-Lambert45.60mg
Heavy MetalsTotal Quantity<20 ppb
TAMCAerobic Count0 CFU
TYMCYeast & Mold0 CFU
cGLP · USP Standards
PRIOR BATCH6-PANELSELECTED DOSAGE
99.7%
PURITY
Passed full 6-panel
View COA
VariantMOTS-c 10mg
Lot #
Labeled10mg
Actual10.35mg
TestedFeb 27, 2026
FULL 6-PANEL6× tested
Qualitative IDLambda MaxConfirmed
Percent PurityCorr. Coeff.99.7%
Quantitative AssayBeer-Lambert10.35mg
Heavy MetalsTotal Quantity<20 ppb
TAMCAerobic Count0 CFU
TYMCYeast & Mold0 CFU
cGLP · USP Standards

Storage & Handling

Stability information
Protect from direct lightAvoid repeated freeze/thaw cyclesReconstitute before use
Lyophilized (powder)
-20°C · 24+ months
Reconstituted
2–8°C · ~30 days

Molecular Profile

Technical specifications
Available Sizes10mg, 40mg
SequenceMet-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Weight~2174.6 g/mol
CAS Number1627580-64-6
FormatLyophilized peptide
Purity≥99% (HPLC)

Frequently Asked Questions

MOTS-c
Is MOTS-c for human use?
No. It is supplied strictly as a research-grade reference material for laboratory use, not for human or animal consumption.
What is a mitochondrial-derived peptide?
MOTS-c is encoded within mitochondrial DNA rather than the nuclear genome, a feature that defines this peptide class.
What purity is the material?
Each batch is independently tested and ships with a batch-specific Certificate of Analysis at greater than or equal to 99% purity by HPLC.
How is it stored?
Store lyophilized at -20°C; after reconstitution, refrigerate at 2-8°C and avoid repeated freeze-thaw cycles.

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